Causes of Excess uric acid in the body

Before discussing about the causes of gout, it is worth first we find out about what actually uric acid that. The cells of animals, human beings are no exception, has a structure called DNA near the cell nucleus. When cells die, the DNA in these cells will be broken down into amino acids constituting material IE. Of the several types of amino acids there are, there is an amino acid called purin, which are then processed by the body into other chemicals. The body metabolize chemicals resulting from purin, with uric acid as a product discharge. Uric acid is what should be filtered by the kidneys to disposed of the body through the urine.

High levels of uric acid in the blood if not promptly treated can cause a buildup of uric acid in the kidneys. Uric acid that accumulates can also form crystals in the joints and surrounding tissue disease called gout.

The cause of Gout based on the mechanism of production and its removal
Mechanism of the formation of uric acid and its removal from the body at a glance looks complicated. But with know it, we can understand what causes a buildup of uric acid in the body. Seen from the production process as well as its removal, the following are possible causes of uric acid in the body is experiencing an increase in:

The number of cells in the body die
Uric acid is a waste product of purin treatment. Purin is one amino acid constituents of DNA, which will break down so the cell undergoes death. Therefore, individuals with high load of dead cells susceptible to buildup of uric acid. Typically, individuals who suffer from cancer (including blood cancer, lymphoma, and multiple myeloma), or who are undergoing cancer therapies such as chemotherapy, have more dead cells in his body.

This is due to the release of dead cells quickly into the bloodstream in patients with cancer and is undergoing chemotherapy. In cancer therapy, chemotherapy does not only kill cancer cells but also cells that are still healthy. Therefore, on the individual there will be a lot more DNA described became purin, which causes uric acid increased.

In addition to cancer, there are other medical conditions that cause uric acid in the body is increased, such as hemolytic anemia and sickle cell anemia (sickle cell anemia). Hemolytic anemia anemia is a disease that occurs when red blood cells are experiencing death faster than the speed of bone marrow produce red blood cells.

While in sickle cell anemia, there is an abnormality of red blood cells form a properly rounded and flexible to be Crescent shaped and hard. The shape of the red blood cells that causes transport nutrients and oxygen throughout the body. The lack of nutrients and oxygen cause more cell body undergoes death compared to individuals with normal red blood cells.

Kidney disease
One of the causes of uric acid in the body is increased when a person suffers from a kidney disease, in which the ability of the kidneys to filter waste is reduced. In this case, although the production of uric acid in the body, the kidneys become unable take it out of the body normally, which causes the levels of uric acid in the blood is increased. Instead, the buildup of uric acid in the blood can also cause kidney stones or kidney failure.

Certain drugs
If you are in a time of treatment, certain drugs you consume may affect the levels of uric acid in your blood. These drugs are diuretics (drugs which is to increase production of urine), vitamin B3, vitamin C, aspirin low dose (75-100 mg per day), the anti-clotting drugs, medicines, the immunosuppressant of L-dopa (a cure for Parkinson's disease) , and some kind of drug relapse.
Obesity
We have learned that a person with excess body weight is extremely vulnerable to experiencing a variety of health problems. Not only are they experienced the limited ability of motion and quickly tired. Hypertension, cholesterol, diabetes, strokes, respiratory disorders, and heart disease is just a little of the many problems that lurk the obesity sufferers. And now, increased one more health risks will appear for people with obesity, i.e., increased levels of uric acid.

Through some research, obesity is believed to be also as one of the causes of uric acid in the body is increased. This is because fatty tissue is believed to be able to increase the production of uric acid. Two things are intertwined this should be able to provide enlightenment for those who suffer from obesity, that it's time for You so that the strengthening and improvement of lifestyle commitment to lose weight and achieve a healthier life.

Before prescribing the drugs, usually the doctor will first recommend exercise for patients with obesity. To lose weight, a recent study published in JAMA Oncology shows that the optimal amount of time needed to work out is 300 minutes a week, with medium intensity or high. Of course, it's possible to lose weight through exercise of less than 300 minutes a week. The principle is, calories burned should be more of the calories in. .. To that end, diet modification is also indispensable.

A diet high in purin
Talk about diet, the intake of foods that contain a lot of purin is also one of the causes of uric acid in the body is increased. In addition to being produced by the body naturally, one type of amino acid is also found in food.

The types of foods you should limit because of the content of purinnya is very high among other organ meats (liver, kidney, and brain), red meats (including beef, lamb, and pork; all the four-legged), meat from animals that are hunted (not are farmed), several the type of fish (sardines, herring, mackerel), and shellfish. Alcohol consumption should also be avoided.

In addition to foods with a very high content of purin, there kinds of foods are also high in nutrients but experts purin still allow it to eat it once in a while, such as seafood other than fish and shellfish-ikanan besides that listed above. Although there are several types of foods that you should limit the number of asupannya, do not worry about a shortage of nutrients. There are still many other types of food that has nutritional value that are safe for your consumption.

Tomatoes, fruits, legumes, and green vegetables, for example, not only low purin but contains iron, folic acid, calcium, and other vitamins. Butter, cheese, and eggs also contain a low purin (though that foodstuffs should You beware if you have high cholesterol levels). While alcohol can You replace with chocolate, cocoa, coffee, and tea.

Of the various possible causes of gout that has been outlined above, we eventually find out that the occurrence of elevated levels of uric acid in the body could be the beginning of something that is not simple. Nevertheless, by knowing accurately the cause, proper handling to lower the levels of uric acid will be done. Hopefully this article is beneficial to us all.